Chronic colitis promotes secondary liver injury through disruption of the gut–liver axis, whereby intestinal barrier breakdown enables portal translocation of microbial products that activate hepatic inflammatory and fibrogenic pathways. Palmitoylethanolamide (PEA), an endogenous ALIAmide acting primarily via PPAR-α, e...
Irene Palenca, Silvia Basili Franzin, G. Sarnelli et al.· Frontiers in Pharmacology· 0 citations
Angiogenesis is a major determinant of tumor growth, progression and metastatic potential, and its persistent activation is closely intertwined with chronic inflammation. This relationship is particularly relevant in malignancies that arise through a prolonged inflammation-to-carcinogenesis continuum, where pathologica...
Irene Palenca, G. Sarnelli, Giuseppe Esposito· Biomedicines· 0 citations
Functional dyspepsia (FD) is a disorder of gut–brain interaction affecting approximately 7% of the global population under Rome IV criteria, characterised by postprandial fullness, early satiation, epigastric pain, and/or epigastric burning in the absence of identifiable organic disease. Meal ingestion is the dominant...
Luisa Bertin, C. Van de Bruaene, E. Formisano et al.· Nutrients· 0 citations
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