INTRODUCTION: Plasma phosphorylated tau217 (pTau217), neurofilament light chain (NfL), and multimodal dementia risk scores may predict development of dementia, but their relative and combined predictive utility remains unclear. METHODS: Data from 3935 participants (aged 58 to 91 (mean =68.3) years) of the Norwegian Tro...
J. Stubs, E. Langballe, G. Livingston et al.· medRxiv· 0 citations
It is observed that midlife mental health problems were associated with higher frailty levels three decades later, across two commonly used frailty models, underscore the importance of both psychological and physical factors in ageing.
I. L. Kyrdalen, G. Selbæk, E. Hoogendijk et al.· Archives of gerontology and...· 0 citations
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
iNPH seems to affect phonemic fluency more and memory less than AD, and as the disease progresses, the cognitive profiles become more similar, and the conditions cannot be distinguished by cognitive tests.
Magnhild S. Dejgaard, P. K. Eide, G. Tangen et al.· Journal of Alzheimer's Disea...· 0 citations
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