Author

G. Tamgüney

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Open access Sep 2026

α‐Synuclein Aggregate‐Disassembling Compounds Prolong Survival in a Mouse Model of Parkinson's Disease

Pathological aggregation of α‐synuclein drives neuronal loss in Parkinson's disease. We therefore tested two optimized all‐d‐peptides, SVD‐17 and SVD‐1a, alongside the prototype SVD‐1. Surface plasmon resonance revealed that SVD‐17 binds monomeric α‐synuclein with a nanomolar KD of 1.09 nM. In vitro, SVD‐17 and SVD‐1a...

Sara Reithofer, Marc M. Sevenich, Madita Vollmer et al. · Aggregate · 0 citations

Open access Aug 2026

Liquid-liquid phase-separated tau colocalizes with and stabilizes Aβ oligomers

It is demonstrated that tau condensates act as reservoirs for Aβ oligomers under liquid-liquid phase separation conditions, with Aβ oligomers reducing tau dynamics, potentially providing a conducive environment for Aβ oligomer clustering.

Tina Jacob, Marie P. Schützmann, Laurin Gerhards et al. · Communications Chemistry · 0 citations