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Author

G. Carullo

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Review Open access Oct 2026

Focus on Azole-Based and Other N-Containing Heterocycles Within the Landscape of Current Structural Classes as Feline McDonough Sarcoma-Like Tyrosine Kinase 3 (FLT3) Inhibitors for Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) is the most common form of acute leukemia. It is characterized by unfavorable prognosis, elevated rates of recurrence, short overall survival and high mortality rates. Genetic and epigenetic aberrations contribute to its initiation and progression, presenting a considerable clinical challen...

Giovanna Panzeca, Nicola Tardiolo, S. Butini et al. · 0 citations
Open access Oct 2026

HDAC3 degradation to uncover therapeutic vulnerability in colorectal cancer.

Overcoming therapeutic resistance in colorectal cancer (CRC) remains a major clinical challenge, highlighting the need for strategies targeting epigenetic drivers. Targeted protein degradation emerged as a powerful approach to selectively eliminate disease-relevant proteins. We reported the development of two series of...

Ilaria Cursaro, Gabriele Carullo, C. Cosenza et al. · 0 citations
Jun 2026

Integrated structure-based and fragment-guided design of isonicotinic acid derivatives as potential KDM4A inhibitors: an insilico study

A structure-based virtual screening workflow was implemented to optimize the known KDM4A inhibitor QC6352 and design novel isonicotinic acid derivatives with improved predicted binding affinity and dynamic stability and introduces promising scaffolds for KDM4A-targeted drug design.

Kourosh Eslami, Hajar Sirous, Ilaria Cursaro et al. · 1 citation

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