Review
Open access
Aug 2026
Metabolic dysfunction and insulin resistance in depression: mechanisms, evidence, and therapeutic implications
Major depressive disorder (MDD) remains one of the most frequently diagnosed mental health disorders and a leading cause of disability worldwide. The discovery of new treatments for MDD is necessary given up to 30% of individuals with MDD are resistant to current antidepressant treatments. The significant physiological...
K. Palacek, O. Corbeil, Saguna Katyal et al.
· Frontiers in Psychiatry · 0 citations