Author

Gabrielle Fredman

2 papers indexed here

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Open access Oct 2026

Transcriptional regulation and function of GPR18 in macrophage subtype specification.

Resolution of inflammation is mediated in part by agonists that engage immune cells to dampen inflammatory signaling, promote phagocytic functions, and facilitate tissue repair. G protein-coupled receptor 18 (GPR18) has emerged as an important proresolving receptor that is activated by endogenous mediators including Re...

Hebe Agustina Mena, Andreas Patsalos, Jake Altomare et al. · Proceedings of the National... · 0 citations

Open access Sep 2026

Combining pro-resolving therapy with cyclosporine A restores immune homeostasis and reduces toxicity in autoimmune bone marrow failure.

Immunosuppressive therapies (ISTs), including calcineurin inhibitors like cyclosporine A (CsA), are essential therapeutics for autoimmunity; however, they often fail and cause dose-limiting toxicity. Severe aplastic anemia (SAA) is a fatal autoimmune bone marrow (BM) failure disorder that is treated with ISTs. BM singl...

Rachel Grazda, Amber Bahr, Lily Nti-kyeremeh et al. · Cell Reports Medicine · 0 citations