Sep 2026
DDR1 sustains ferroptosis resistance in pancreatic ductal adenocarcinoma via SLC40A1-mediated iron homeostasis.
Chao Song, Lu-Ting Zhang, Sheng Xu et al.
· Oncogene · 0 citations
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Open access
Sep 2026
Multi-omics and spatial transcriptomics reveal that S100A10 drives CD8+ T-cell exhaustion and immune evasion in hepatocellular carcinoma through cPLA2-5-LOX-mediated arachidonic acid metabolism and ferroptosis.
Immune evasion in hepatocellular carcinoma (HCC) represents a major biological barrier limiting the efficacy of immunotherapy, yet its molecular basis remains incompletely understood. Increasing evidence indicates that tumor metabolic reprogramming and ferroptosis-related signaling play critical roles in shaping an imm...
Jing-Xu Zhang, Gang-Gang Wang, Zhijie Zhou et al.
· International Immunopharmaco... · 0 citations