Metabolic control of methylation landscapes in cancer growth and plasticity: targeting the epigenetic–metabolic axis with natural compounds and emerging therapies
Cancer cell plasticity enables tumor cells to dynamically transition between diverse phenotypic states, including epithelial–mesenchymal plasticity stemness, dormancy, lineage switching, immune evasion, and therapy-resistant phenotypes. Although metabolic reprogramming and epigenetic regulation have each been recognize...