Gang Lu

Early adjunctive vasopressin was not associated with a lower 7-day risk of renal replacement therapy in norepinephrine-treated patients with cirrhosis: a target-trial-informed study with external replication

Background Early adjunctive vasopressin can reduce catecholamine exposure in vasodilatory shock, but whether it prevents severe kidney failure in norepinephrine-treated patients with cirrhosis is uncertain. Methods We conducted a target-trial-informed landmark study using MIMIC-IV as the primary cohort and eICU-CRD as...