Author

Gang Wan

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Open access Sep 2026

Introns encode a vast new class of Kink-loop RNAs that autoregulate pre-mRNA splicing

Functional and genetic perturbations establish that klRNAs suppress host intron excision through a K-loop-dependent mechanism and establish klRNA-mediated autoregulation as a widespread principle governing intron fate.

Bin Li, Q. Lin, Anrui Liu et al. · bioRxiv · 0 citations

Open access Aug 2026

Introns encode a vast class of Kink-loop RNAs that autoregulate pre-mRNA splicing

Introns occupy nearly one-third of the human genome, yet whether they encode widespread regulatory functions remains unclear. Here, we identify a pervasive class of intron-derived Kink-loop RNAs (klRNAs) that locally control pre-mRNA processing. Using complementary enrichment strategies, we uncovered approximately 15,2...

Bin Li, Q. Lin, Anrui Liu et al. · bioRxiv · 0 citations