Rosmarinic Acid Inhibits β-Sheet and β-Hairpin Formation in Human Islet Amyloid Polypeptide Dimers by Stabilizing Localized C-Terminal Motifs: An REMD Study
The misfolding of human islet amyloid polypeptide (hIAPP) into soluble oligomers is a primary pathological event in type 2 diabetes, with the early dimerization process representing a critical pharmacological target. Here, we investigate the molecular mechanism by which rosmarinic acid (RA) counteracts full-length hI...