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Open access Aug 2026

METTL7A‐Dependent m6A Methylation Orchestrates CXCR4hi Neutrophil Pathogenicity and NETosis in Skin Inflammation

Neutrophil extracellular traps (NETs) released by C–X–C motif chemokine receptor 4‐high (CXCR4hi) neutrophils are major contributors to skin inflammation in psoriasis, yet the upstream epitranscriptomic mechanisms that regulate NETosis remain poorly defined. Here, we investigated the role of methyltransferase‐like prot...

Wan-Ting Liu, Jinkai Liang, Hui-Yi Quan et al. · 0 citations
Open access Aug 2026

Shared Treg dysregulation underlies psoriasis vulgaris and atopic dermatitis through the PHF19-PRC2 epigenetic axis

Background Psoriasis vulgaris (PV) and atopic dermatitis (AD) are chronic inflammatory skin diseases characterized by distinct dominant T cell subsets, yet emerging evidence suggests overlapping immune mechanisms. Whether a shared Treg abnormality underlies both diseases remains unclear. Methods Single-cell RNA sequenc...

Yi-Ting Lin, Xiao-Lei Su, Ming-Zhu Jin et al. · 0 citations

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