Structural Modification of Antifungal Acylphloroglucinols against Cryptococcus Species
A previously reported natural product-derived acylphloroglucinol, 2-methyl-1-(2,4,6-trihydroxy-3-(4-isopropylbenzyl)phenyl)propan-1-one (1), exhibited potent in vitro antifungal activity against Cryptococcus species, the causative agents of life-threatening cryptococcosis. To further investigate the structure−activit...