Sep 2026
Input-Triggered Allosteric Activation of CRISPR-Cas12a by Modular Loop-Engineered Hairpins.
Achieving precise control over CRISPR-Cas12a activity remains a fundamental challenge in the development of versatile sensing platforms, particularly for applications in diagnostics. Herein, we report an allosteric strategy that employs modular loop-engineered hairpin (MLEH) to precisely control Cas12a activation, ther...
N. Yin, Li Zhang, Rui-Ling Lu et al.
· ACS Sensors · 0 citations