Author

Gang Zhou

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Editorial Open access Sep 2026

Editorial: Targeting the Wnt/β-catenin signaling pathway in cancer, volume II

this Research Topic. In lung adenocarcinoma (LUAD), miR-582-3p promotes Wnt/ b -catenin pathway activation through suppression of PTPRCAP, whereas WTAP-mediated m6A modi ﬁ cation decreases SOX2 mRNA stability and limits SOX2-dependent Wnt/ b -catenin signaling. In triple-negative breast cancer (TNBC), SOX10 acts as an...

S. Patergnani, D. Buchsbaum, Gary A. Piazza et al. · Frontiers in Oncology · 0 citations

Jul 2026

Abstract B005: ADT-030, a novel PDE10 inhibitor that blocks RAS and β-catenin signaling with robust and durable antitumor activity and potential to mitigate resistance and on-target toxicities of monospecific RAS inhibitors

Multiple cancers arise from co-occurring mutations that activate RAS/MAPK and Wnt/β-catenin signaling pathways, which cooperate to drive tumorigenesis, metastasis, and drug resistance. A dual inhibitor of RAS and β-catenin signaling may offer a more effective therapeutic strategy compared with monospecific inhibitors...

Xi Chen, D. Bandi, G. P. Nagaraju et al. · Clinical Cancer Research · 0 citations