CREBBP mutation promotes tumor growth and CD8+ T-cell dysfunction in DLBCL via NOTCH-STAT1-LGALS9 signaling
Epigenetic reprogramming is increasingly recognized as a key driver of clonal evolution and therapeutic resistance in diffuse large B-cell lymphoma (DLBCL), yet how epigenetic mutations shape the tumor microenvironment (TME) remains unclear. Here we investigated the recurrent CREB binding protein (CREBBP) Y1503C mu...