TLSB-01 A PAN-CANCER MULTI-OMIC CLASSIFICATION OF BRAIN METASTASES REVEALS ACTIONABLE METASTATIC STATES AND A METABOLIC–IMMUNE BIOMARKER AXIS TO GUIDE RATIONAL COMBINATIONS
A pan-cancer metastatic state framework is established to link it to actionable biomarkers and validated therapeutic hypotheses, and provide an evidence base for biomarker-guided clinical trials that pair metabolism-targeting with immunotherapy for metabolically reprogrammed, immune-suppressed BrMs, and inform companio...