Gary H. Karpen

Outside-in progression of heterochromatin replication and exclusion of CDC45 from the PCH domain in Drosophila

Heterochromatin replication isn’t random or uniform, but occurs in a characteristic spatial and temporal pattern. Previous studies produced conflicting models for pericentric heterochromatin (PCH) replication, suggesting either that heterochromatic sequences translocate to the domain surface for replication, or that re...

ORC binding to Heterochromatin Protein 1 through intrinsically disordered regions is required for heterochromatin structure and function