Open access
Aug 2026
Sorting of lysosomal enzyme and autophagy are regulated by the GGA1-induced TGN lipid scrambling
The physiological role of lipid asymmetry in intracellular membranes remains poorly understood. Here, we show that sphingomyelin (SM), typically confined to the lumen of the trans-Golgi network (TGN), is exposed on its cytoplasmic surface by the action of the Golgi-associated protein, Golgi-associated gamma-adaptin ear...
Kohta Takahashi, Nario Tomishige, Mitsuhiro Abe et al.
· Science Advances · 0 citations