Author

Gautam Sethi

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Review Open access Jul 2026

Tumor-specific mechanisms and therapeutic strategies for overcoming immunotherapy resistance in advanced urological tumors.

Overall, immunotherapy resistance in urological malignancies is a multifactorial and dynamic process involving tumor, microenvironmental, and host determinants, and a comprehensive, mechanism-driven approach integrating biomarker-guided strategies and combination therapies is essential to improve clinical outcomes and...

Pin-Ying Wang, Bohan Zhang, Yaxing Shi et al. · Journal of Advanced Research · 1 citation

Open access Jul 2026

TRIM27-Cas9-loaded EVs suppress HCC proliferation and enhance responsiveness to anti-PD-1 therapy by promoting ACSL4-mediated ferroptosis.

It is suggested that TRIM27 confers ferroptosis resistance via facilitating K48-linked ubiquitination and subsequent proteasomal degradation of ACSL4 and developed TRIM27-Cas9-loaded EVs with robust editing efficiency.

Jie Wen, Zhihui Wang, Zhirui Zeng et al. · Cell Death and Differentiati... · 1 citation

Review Aug 2026

Overcoming immune resistance through tumor microenvironment reprogramming: Emerging immunotherapeutic strategies and translational advances.

Advances in antibody-drug conjugates, cancer vaccines, and adoptive cellular therapies are discussed as promising strategies that combine targeted cytotoxicity with immune activation.

Vivek Uttam, Sia Daffara, Sandeep Singh et al. · Biochemical Pharmacology · 0 citations