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Author

Gayathri Srinivasan

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Open access Oct 2026

Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder influenced by both causal mutations and genetic modifiers. The rare APOE3 Christchurch (APOE3ch) variant has been associated with delayed disease onset in a familial Alzheimer’s disease case, suggesting a potential protective role. However, the me...

Carlye Frisch, Lauren Baker, Gayathri Srinivasan et al. · 0 citations
Open access Aug 2026

Development of a human iPSC and patient phenotyping resource for preclinical investigations of neurodevelopmental disorders.

An integrated collection of genetically defined iPSC lines and associated clinical data provides a powerful platform for investigating disease mechanisms and advancing iPSC-based drug discovery for NDDs.

Ci-Di Chen, Wardiya Afshar-Saber, I. Iglesias et al. · 0 citations

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