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Open access Sep 2026

Phosphoregulation of hierarchical protein condensate formation during clathrin-mediated endocytosis

The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood. Biomolecular condensation is proposed to orchestrate CME, but defining biophysical parameters in vivo remains challengi...

Yi-Di Sun, Andrew Wong, Ge-An Hu et al. · 0 citations
Review Open access Aug 2026

Interpretable biophysical neural networks of transcriptional activation domains separate roles of protein abundance and coactivator binding.

Deep neural networks have improved many difficult prediction tasks in biology, but it remains challenging to interpret these networks and learn the molecular mechanisms. Here, we address interpretation challenges by building biophysical neural networks for predicting activation domains, the regions within transcription...

Claire LeBlanc, Pooja Agarwal, Jack E. Demaray et al. · 0 citations

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