Author

Gene W. Yeo

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Review Open access Sep 2026

RNA dysregulation as a determinant of aging and neurodegenerative vulnerability.

In the nervous system, aging causes deterioration of cellular and molecular processes that are associated with declines in cognition, sensory perception, and motor coordination. Aging is also the strongest risk factor for neurodegenerative disease, yet the mechanisms by which aging predisposes neurons to dysfunction re...

Sawyer Randles, Gene W. Yeo · Trends in Cell Biology · 0 citations

Open access Jul 2026

ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing

ESAPE (Endogenous Site-specific Competition Assays using Prime Editors using Prime Editors), a platform for the site-resolved functional analysis of covalent ligands in cells, identifies multiple covalent ligand-protein interactions that impair cancer cell growth.

Jason Tse, William R. Brothers, Rachel E. Hayward et al. · bioRxiv · 0 citations