Author

Gengyi Zou

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Open access Sep 2026

CRACD loss drives hypoxia-induced immune escape in gastric cancer

Mucinous gastric adenocarcinoma (MGC) is a distinct histologic subtype characterized by poor prognosis and limited responsiveness to chemotherapy and immunotherapy. CRACD, an actin polymerization regulator, is frequently inactivated in gastric cancer (GC), with enrichment in mucinous subtypes. We found that genetic...

Yoojeong Seo, Jinho Jang, Kyung-Pil Ko et al. · Nature Communications · 0 citations

Open access Aug 2026

Pharmacologic Inhibition of SOX9-CDK4 by CYD-4-61 Impairs Gastric Adenocarcinoma Growth and Amplifies Anti-PD-1 Response.

Findings identify the BAX-SOX9-CDK4 axis as an important mechanism contributing to the antitumor activity of CYD-4-61 and provide a strong preclinical rationale for its further development as a therapeutic strategy for aggressive GAC.

Geng-Yi Zou, Katsuhiro Yoshimura, Yibo Fan et al. · Cancer Letters · 0 citations