Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface.
Mechanosensation is fundamentally viewed as a plasma membrane phenomenon. We challenge this paradigm by introducing intracellular mechanosensation in intestinal smooth muscle. We hypothesized that a distinct, organelle-based signalling axis exists to amplify mechanotransduction from the inside out. To test this we inve...