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Author

George B. Stefano

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Open access Oct 2026

Synthetic cells: Potential benefits and risks of interactions with commensal and pathogenic microorganisms

Synthetic cells are shifting biology from the observation and modification of existing life toward the deliberate construction of cell-like systems. The term, however, includes two biologically different entities: bottom-up protocells assembled from nonliving molecular components and top-down cells whose natural genome...

George B. Stefano · 0 citations
Open access Aug 2026

Beyond defense: Immunity as an evolutionary network for preserving biological organization from microbes to complex life

Biological evolution has produced increasing organizational complexity, from molecular systems to integrated multicellular organisms. Natural selection explains why advantageous variation persists, but sustaining increasingly complex living systems also requires mechanisms that preserve functional organization while al...

George B. Stefano · 0 citations

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