Open access
Oct 2026
WEE1 opposes APC/CCDH1 activity to promote S phase entry.
WEE1 phosphorylates and inhibits the activity of cyclin-dependent kinases to prevent mitotic entry and establish a G2 DNA damage checkpoint1-3. Consequently, WEE1 inhibitors have been developed to be synthetically lethal in TP53-mutated tumours that become reliant on this WEE1-mediated checkpoint, and such inhibitors a...
Luc-Alban Vuillemenot, Lucas G. Morales, Calin-Mihai Dragoi et al.
· Nature · 0 citations