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Author

Geraldine Zimmer-Bensch

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Open access Aug 2026

Disease-Associated Mutations Impact DNA Methyltransferase 1 Function through Dynamic Allosteric Effects and Solvent Exposure

Mutations in the DNA methyltransferase 1 (DNMT1) enzyme can lead to neurodegenerative diseases, including autosomal dominant cerebellar ataxia–deafness and neuropathy (ADCA-DN) and hereditary sensory and autonomic neuropathy type 1E (HSAN1E). The impact of these mutations on the structural dynamics of DNMT1 remains lar...

Song Xie, Can Bora Yildiz, Paolo Ruggerone et al. · 0 citations
Open access Jul 2026

A new set of DNA methylation variants in the human genome show predominant tissue-specificity and sensitivity to reprogramming with a potential for disease susceptibility

MeVars have postzygotic origins with an ability to ‘reset’ during reprogramming, adding a new dimension in the form of epigenetic diversity and its relevance to disease susceptibility in humans.

Anuhya Anne, Lov Kumar, Monica Singh et al. · 0 citations

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