Author

Gerhard Hummer

3 papers indexed here

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Open access Sep 2026

Structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III

In open mitosis, re-establishing nucleocytoplasmic compartmentalization requires the LEM2-ESCRT machinery to coordinate spindle clearance with sealing of the remaining nuclear envelope pores. The structural basis of this topologically unique and fundamental membrane-remodeling process is poorly understood. Here, we com...

Mareike A. Jordan, Karen Palacio-Rodríguez, Ramesh Adakkattil et al. · bioRxiv · 0 citations

Open access Oct 2026

A selectivity filter in Tim17 mediates intramitochondrial protein sorting

Mitochondria import hundreds of proteins into the matrix and the inner membrane (IM). The translocase of the IM of mitochondria (TIM23 complex) sorts these proteins using topogenic signals in their structure and directs them into the matrix or inserts them into the IM. How these signals are deciphered is unknown. Her...

Annika Egeler, Sanjoy Paul, Rosario Valenti et al. · Nature Communications · 0 citations

Open access Jul 2026

Identification of lipid specificity in membrane organizing protein complexes

Using super-resolution microscopy and molecular dynamics simulations, it is demonstrated that phosphatidylethanolamine stabilizes both NDC1 and MIC60 in highly curved membrane nanodomains, indicating that major membrane organizing complexes are positioned by selective lipid-protein interactions.

Katelyn C. Cook, Karen Palacio-Rodríguez, Kristi Bohlig et al. · bioRxiv · 1 citation