Open access
Aug 2026
Development and pharmacokinetic evaluation of novasomes encapsulated roflumilast loaded nanoparticles of thiolated chitosan for transnasal delivery
Bioavailability of roflumilast (RFT) upon oral administration is decreased because of gastrointestinal adverse effects and hepatic first pass metabolism. Nasal administration might increase the bioavailability of RFT and its quick onset of action because phosphodiesterase-4 inhibitors are present in several lung area...
Maira Tahir, Shahid Shah, A. Rasul et al.
· Journal of King Saud Univers... · 0 citations