Open access
Sep 2026
Programmable in vivo mRNA circularization for enhanced gene expression in bacteria
Abstract The minute-scale lifetime of mRNA strongly influences bacterial gene expression, whereas a robust and programmable approach to directly control the mRNA stability and topology remains elusive. Here, we develop CRESEnT (Circular RNA Expression for Stable and Enhanced Translation), a programmable in vivo mRNA ci...
Seongjun Park, G. Kim, Min Ha Kim et al.
· Nucleic Acids Research · 0 citations