Open access
Oct 2026
ATF6 shapes PERK and IRE1 signaling dynamics during ER stress
The Unfolded Protein Response (UPR) is a conserved network of signaling pathways controlled by the Endoplasmic Reticulum (ER) anchored stress sensors IRE1, PERK and ATF6. The UPR’s primary function is to help cells manage and resolve ER stress. Compared with the well-characterized IRE1 and PERK pathways, how ATF6 sha...
Gideon Ong, Masozi Palata, Suraj Shaji et al.
· Cell Death & Disease · 0 citations