Author

Gillian Clifford

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Open access Sep 2026

Auxin-inducible degron-mediated protein depletion in Diplonema papillatum

Diplonemids are highly abundant unicellular flagellates that are evolutionarily divergent from traditional model eukaryotes. Diplonema papillatum is a model diplonemid for which several molecular tools have recently been established. However, no method for conditional protein depletion was available. Here, we have adap...

Gillian Clifford, Bungo Akiyoshi · bioRxiv · 0 citations

Open access Aug 2026

Disease mutations in the PWWP domain of DNMT3A affect chromatin recruitment through multiple mechanisms

Understanding of the molecular mechanisms by which DNMT3A PWWP-domain mutations are mechanistically heterogeneous is advanced, providing a biochemical framework that contributes to distinct disease phenotypes.

Hannah Wapenaar, Gillian Clifford, Francesca Taglini et al. · bioRxiv · 0 citations