Author

Giovanna Ambrosini

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Open access Aug 2026

Extensive binding of poorly characterized human transcription factors to genomic dark matter

It is found that induction of TPRX1, a known regulator of zygotic preimplantation, leads to chromatin opening at many of its binding sites in the dark matter genome, suggesting that the genome encodes many putative transcription factors.

Rozita Razavi, Ali Fathi, Isaac Yellan et al. · Nature Communications · 3 citations

Review Open access Aug 2026

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors

There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present genomic high-throughput SELEX (GHT-SELEX)—a scalable method t...

A. Jolma, A. Hernandez-Corchado, A. Yang et al. · Nature Methods · 3 citations