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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Giovanna Paolone

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Open access Sep 2026

Aging is associated with behavioral alterations, lysosomal dysfunction, region-specific inflammation, and glutamatergic synaptic impairments in a Grn knockout mouse model of frontotemporal dementia

Progranulin-related frontotemporal dementia ( GRN -FTD) is an inherited neurodegenerative disorder caused by progranulin (PGRN) deficiency. Although PGRN functions are well characterized and several therapeutic strategies aiming to restore its levels are currently under evaluation, the mechanisms linking PGRN los...

Chiara Bertasini, Maria Italia, Shima Tavakolian Haghighi et al. · 0 citations
Review Open access Aug 2026

HIV-1 Tat and gp120 as key drivers of neurodegeneration in the central nervous system

Converging data achieved from in vitro models, Tat and gp120-transgenic mice, post-mortem tissue, and cerebrospinal fluid biomarkers indicate that these viral proteins contribute to frontostriatal atrophy and hybrid HAND-AD phenotypes increasingly observed in aging HIV patients.

R. Cecchetto, Erica Diani, V. Lotti et al. · 0 citations
Review Open access Jul 2026

RNA Splicing Dysregulation in Parkinson’s Disease

Current evidence on the RNA regulatory networks in PD is examined, highlighting the role of transcript isoforms and RBPs in neuronal dysfunction and emerging data suggest that dysregulation of RNA binding proteins (RBPs) may influence RNA processing in PD.

Maria Giusy Bruno, G. Menichetti, Angela Valentino et al. · 0 citations

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