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Author

Giovanni Parmigiani

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Nov 2026

Abstract 6313: Integration of Genomic and Lab Data with Dynamic EHR Modeling

Background: Polygenic risk scores (PRS) for cardiovascular disease are almost always used as static covariates in proportional-hazards (PH) models - a single number, fixed for life. However, genetic effects on coronary artery disease (CAD) and other CV outcomes are non-stationary, rising and falling with age; when g...

S. Urbut, Giovanni Parmigiani, Alexander Gusev et al. · 0 citations
Open access Jul 2026

Familial Risk Stratification Across Cancer Syndromes Using Fam3PRO

Fam3PRO provides a validated approach for familial risk stratification across a broad spectrum of cancer types, including estimates of carrier probabilities and future cancer risk, and is validated on three independent multi-ethnic panel cohorts.

Jane W. Liang, Gregory E. Idos, C. Hong et al. · 0 citations

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