Engineered probiotic-mediated palmitoylethanolamide biosynthesis protects against colitis-associated liver injury
Chronic colitis promotes secondary liver injury through disruption of the gut–liver axis, whereby intestinal barrier breakdown enables portal translocation of microbial products that activate hepatic inflammatory and fibrogenic pathways. Palmitoylethanolamide (PEA), an endogenous ALIAmide acting primarily via PPAR-α, e...