Author

Glenn R. Masson

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Open access Sep 2026

Structural Basis for Activation of HRI by the DELE1 C-terminal domain

Haem-Regulated Inhibitor (HRI, aka EIF2AK1) is one of four stress-sensing kinases that phosphorylate eIF2α as part of the integrated stress response (ISR). HRI was first characterized as a haem-sensing kinase where it is inhibited when bound to haem. Recent studies have revealed another role for HRI in sensing mitochon...

O. Raimi, Rupam Bhattacharjee, Min Cao et al. · bioRxiv · 0 citations

Open access Aug 2026

USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage

A non-canonical proteolytic function of USP5 is revealed, uncovering a previously unrecognised regulatory axis linking deubiquitinating enzymes to protein maturation, expanding the substrate repertoire for USP5 and providing a framework for identifying protease–substrate relationships in post-translational regulation.

Liam T. Hales, Paul M. Tammiste, Adam J. Walker et al. · Nature Communications · 1 citation