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Oct 2026

Stereoselective Glycosylation of Amides with Glycal Catalyzed by a Solid–Liquid Phase-Transfer and Proton-Transfer Dual-Functional Pyridinium Catalyst

2-Deoxyglycosylamides have great potential for biochemical applications, but their streamlined synthesis remains underexplored. Herein, 2-pentafluorophenylpyridinium tetrafluoroborate was designed for highly stereoselective glycosylation of amides with glycals. Besides the challenging substrates like glucals, the met...

Qin-Bo Jiao, Zhen-Bo Guo, Shuai Jiang et al. · 0 citations
Open access Sep 2026

Macrocyclization of native peptides through (thio)urea crosslinking of two amines

Cyclopeptides have emerged as promising candidates for drug development. However, owing to the scarcity of efficient cyclization strategies for natural peptides, the development of diverse cyclopeptides remains a formidable challenge. In this study, a variety of macrocyclic peptides featuring (thio)urea bridges are dev...

Jin-Yao Liu, Pei-Ru Chen, Mei-Lin Tang et al. · 0 citations

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