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This study suggests a link between RNA decay–mediated regulation of metabolism and genome integrity during germ cell development during germ cell development and reveals disruption of post-transcriptional control as a potential mechanism underlying infertility.
Cth1 is a highly deposited maternal mRNA that undergoes rapid decay 3’UTR of Cth1 drives its spatio-temporal dynamics, establishing Cth1 as a key component of the maternal program and providing the first direct evidence that spatio-temporally regulated mRNA decay, outside the germline, contributes to early vertebrate d...
Maternal mRNA decay is essential for the Maternal-to-Zygotic Transition (MZT), yet its impact on spatial regulation has remained largely unexplored. We identify Cth1 as the first maternally encoded RNA-decay factor regulated in a spatiotemporal manner outside the germline in zebrafish, driven by conserved 3′UTR cis-ele...
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