Immunomodulatory Tr1 CD4 T cells induced by engineered V1-deleted HIV vaccine candidate decrease the risk of SIV acquisition in macaques 2267572
Investigating how the vaccine shapes the CD4+ T cell immunity and how these responses cooperate in reducing the acquisition found that DV1 DNA/ALVAC/gp120 vaccine elicited envelope-specific immunomodulatory Tr1 CD4+ T cells, and that total Tr1 responses were associated with a reduced risk of viral acquisition.