Spike protein derived from an apathogenic IBV strain confers attenuated phenotype to a nephropathogenic IBV strain
ABSTRACT Infectious bronchitis virus (IBV), a Gammacoronavirus, causes the economically damaging disease of poultry, infectious bronchitis. Development of IBV live attenuated vaccines (LAVs) is dependent on the supply of embryonated hens’ eggs and attenuation through serial passaging, upwards of 80 times. Vaccine devel...