Author

Graham R. Moran

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Jul 2026

Bilirubin Reductase from Mediterraneibacter gnavus: Positional Reduction Preferences and Transient-State Analysis.

Single-turnover data correlated with steady-state assays and NMR tracking of the steady-state reaction confirm that BilR can reduce both types of vinylic bonds of bilirubin but appears to have a 4-fold preference for reduction of α-vinylic over enamine bonds that is defined almost entirely by the rate of hydride transf...

Corine O Smith, Graham R. Moran · Biochemistry · 0 citations

Aug 2026

Design and Elucidation of a Strain-Relief-Driven Ring Opening Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3R,5R)-3-Amino-6,6-difluorobicyclo[3.1.0]hexane-1-carboxylic Acid.

Structural and mechanistic studies validated the proposed mechanism of 5, which undergoes a ring-opening mechanism to form a PLP-inactivator adduct that is tightly bound in the active site of hOAT, the first report of a ring-opening event in the active site of hOAT.

Allison N Devitt, Abigail L. Vargas, C. K. Zhang et al. · Journal of the American Chem... · 0 citations

Jul 2026

Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of γ-Aminobutyric Acids.

The rational design, synthesis, and mechanistic investigation of cyclopentene-based γ-aminobutyric acid analogues bearing alkyne or nitrile warheads as potent hOAT inactivators are reported, expanding the mechanistic repertoire of PLP-dependent enzyme inactivation and providing a generalizable framework for designing h...

Feng Wang, M. Corrigan, N. Le et al. · Journal of the American Chem... · 0 citations