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Graziano Oldani

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Review Open access Aug 2026

The Hepatocyte Expansion Paradox: A Review of In Vitro Challenges and Advances

Highlights What are the main findings? Primary hepatocytes are notoriously difficult to maintain long-term in vitro, but defined growth-factor protocols can reversibly convert them into a proliferative, progenitor-like state before restoring maturity. Three-dimensional (3D) culture strategies improve hepatocyte maturat...

Mina Kolahdouzmohammadi, N. Tjandra, Ke Wu et al. · 0 citations

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