The encapsulation of the viral RNA condensate inside the capsid is a crucial step in the late stages of the HIV-1 replication cycle. While it is agreed that RNA encapsulation depends on RNA-bound integrase (IN), that capsid-bound IN-RNA filaments are present within the capsid, and that the ribonucleoprotein (RNP) compl...
Curt Waltmann, Manish Gupta, Alan N. Engelman et al.· bioRxiv· 0 citations
The actomyosin cytoskeleton plays important roles in cell-cell adhesion by generating and responding to forces. Actin-binding proteins support actomyosin networks by reinforcing actin filaments, promoting actin remodeling, and transmitting forces to transmembrane adhesion proteins. One family of actin-binding proteins,...
Katherine K. Tjoelker, Tamsuk Paul, Babli Adhikary et al.· bioRxiv· 0 citations
The immature HIV-1 virion is assembled by the Gag polyprotein using inositol hexakisphosphate (IP6) as an essential assembly co-factor. Gag binds the genomic RNA Psi packaging signal via the nucleocapsid (NC) domain and associates with the plasma membrane via the matrix (MA) domain. Previous studies revealed that Gag e...
Ye-Hong Qiu, Puja Banerjee, Kaylee Grabarkewitz et al.· RNA: A publication of the RN...· 0 citations
A crucial stage of the HIV-1 life cycle is the docking of the viral capsid at, and its translocation through, the nuclear pore complex (NPC). During this process, the capsid interacts with a series of cellular host factors that regulate efficient nuclear entry. One such host factor is cleavage and polyadenylation speci...
A. Hudait, Kuntal Ghosh, Gregory A. Voth· bioRxiv· 0 citations
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