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Author

Gregory M. Chen

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Open access Aug 2026

Decade-long persistence of CD19 CAR T cells in B cell lymphomas

Chimeric antigen receptor (CAR) T cell therapy induces durable remissions in lymphoid malignancies, yet the extent and biology of long-term CAR T cell persistence in B cell lymphoma remain unclear. Here we report the persistence and characteristics of 4-1BB-costimulated anti-CD19 CAR T cells (CART19) up to 10 years aft...

L. Paruzzo, E. Chong, Elise A. Chong et al. · 0 citations
Open access Sep 2026

A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial

Early-phase studies of deep B cell depletion with anti-CD19 chimeric antigen receptor (CAR) T have produced prolonged, drug-free remission in refractory autoimmune disease. However, CAR T cell therapy requires lymphodepleting chemotherapy, autologous cell manufacturing and specialized infrastructure, limiting reach to...

Jason Xu, Chun-Li Mei, Xin Guan et al. · 0 citations

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