Neuronopathic lysosomal storage disorders remain difficult to treat because conventional enzyme replacement therapies generally do not reach therapeutically meaningful concentrations in the central nervous system. Miglustat (1,5-(butylimino)-1,5-dideoxy-D-glucitol; N-butyl-deoxynojirimycin) is an orally administered im...
Patryk Lipiński, Grzegorz Węgrzyn· International Journal of Mol...· 0 citations
The increasing prevalence of antibiotic-resistant uropathogenic Escherichia coli highlights the need for antibacterial strategies that can complement or extend beyond conventional antibiotic treatment. Bacteriophages and phage-derived lytic enzymes represent promising alternatives because of their distinct mechanisms o...
Wojciech Wesołowski, Sylwia Bloch, Grzegorz Czerwonka et al.· bioRxiv· 0 citations
Cyanobacteria of the genus Nostoc, known for their large genomes and rich repertoire of biosynthetic gene clusters, represent a prolific source of structurally diverse secondary metabolites with diverse biological activities, including cytotoxic effects. However, the identification of bioactive compounds is often hinde...
R. Konkel, Marta Cegłowska, Łukasz Grabowski et al.· Molecular diversity· 0 citations
The increasing clinical evidence shows that synthetic biology can effectively overcome the inherent defects of natural bacteriophages, confirming the safety and initial efficacy of bacteriophage therapy.
Xuan Wang, Haolin Zhou, T. S. Lim et al.· International Journal of Mol...· 0 citations
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