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Guan-Hua Xu

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Oct 2026

Ergothioneine promotes functional recovery after spinal cord injury by stabilizing VPS35 to suppress mitochondrial damage-driven neuroinflammation and oxidative stress.

BACKGROUND Spinal cord injury (SCI) triggers a complex secondary injury cascade involving neuroinflammation, oxidative stress, and mitochondrial dysfunction. These interconnected pathological processes exacerbate neuronal damage and hinder functional recovery. However, effective therapeutic strategies targeting these i...

Jian Zhou, Chao-Qiang Zhang, Ya-Nan Zhang et al. · 0 citations
Open access Sep 2026

Hinokitiol Promotes Neural Repair After Spinal Cord Injury by Reprogramming Microglial Inflammatory and Redox Responses.

Hinokitiol supports neural repair after SCI by reprogramming microglial inflammatory-redox states, at least partly through Nrf2 signaling, which justifies further pharmacokinetic, sex-inclusive, and long-term safety studies.

Wen-Hao Zhang, Jing Wang, Tian-Yi Wang et al. · 0 citations
Open access Jul 2026

Association of bone metabolic markers, bone mineral density and clinical characteristics with the occurrence of secondary fractures after PVP/PKP for osteoporotic thoracolumbar fractures: a study on logistic

Age, number of operated vertebrae, cement leakage, PINP, 25(OH)D, and BMD are closely associated with and are independent risk factors for secondary fractures after PVP/PKP in OTF patients, and the nomogram model based on these factors has high value.

Jiawei Fu, Guan-Hua Xu, Jia-jia Chen et al. · 0 citations

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