Open access
Sep 2026
FACT–(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly
DNA replication is an exquisitely regulated process that requires tight coordination at the eukaryotic replication fork, operating within the compacted chromatin environment. Minimizing exposure of naked DNA is critical to prevent nuclease degradation and genome instability, a hallmark of cancer. Cells, therefore, requ...
Wen-Shu Zhang, Shi-Cheng Geng, Jia-Wei Xu et al.
· Science Advances · 0 citations