New carbazole-5-phenoxymethyl-1,2,4-triazole derivatives as multi-target inhibitors towards α-glucosidase, α-amylase and PTP1B: Construction, biological evaluation, and mechanism investigation.
With the aim of developing novel multi-target agents capable of simultaneously inhibiting α-glucosidase (α-Glu), α-amylase (α-Amy), and protein tyrosine phosphatase 1B (PTP1B), a new library of twenty-four carbazole-5-phenoxymethyl-1,2,4-triazole analogues (7a-7x) was synthesized and subjected to enzyme inhibition scre...